Mohrez, Morad and Troeger, Anja and Kleinschmidt, Katharina and Alali, Tarek Hanafee and Jakob, Marcus and Brosig, Andreas and Haehnel, Viola and Kietz, Silke and Offner, Robert and Burkhardt, Ralph and Corbacioglu, Selim and Ahrens, Norbert and Foell, Juergen (2023) Feasibility of peripheral blood stem cell collection from sickle cell trait donors with an intensified G-CSF regimen. EUROPEAN JOURNAL OF HAEMATOLOGY, 111 (5). pp. 824-830. ISSN 0902-4441, 1600-0609
Full text not available from this repository. (Request a copy)Abstract
Objectives: Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative treatment for SCD and bone marrow from an HLA-matched sibling is currently the standard of care. Haploidentical HSCT from a family donor with a TCR alpha beta/CD19 depleted graft (T-haplo) is an increasingly successful alternative, which requires the generation of G-CSF stimulated peripheral stem cell (PBSC) from haploidentical relatives. These sickle cell trait (SCT) donors reported to develop SCD-related complications in conditions of severe stress. Methods: In this retrospective analysis, we compared the safety and efficacy of PBSC mobilization with a G-CSF intensified mobilization regimen in SCT donors with a conventional G-CSF mobilization regimen in healthy donors. Results: The reported adverse events were similar during intensified G-CSF mobilization, apheresis, and shortly after stem cell apheresis in SCT and control donors. In SCT and control donors, we were able to mobilize high yields of CD34(+) stem cells and the harvested CD34(+) cell count was comparable with control donors. Conclusions: Peripheral stem cell mobilization using an intensified G-CSF regimen is safe, and well tolerated among SCT donors. SCT donors are a valid alternative for collection of peripheral CD34(+) stem cells for T-cell-depleted haploidentical stem cell transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLONY-STIMULATING FACTOR; BONE-MARROW-TRANSPLANTATION; MOBILIZATION; INDIVIDUALS; DISEASE; CRISIS; sickle cell trait; sickle cell disease; stem cell mobilization; stem cell transplantation; stem cell harvest |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2024 10:30 |
| Last Modified: | 08 Mar 2024 10:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59133 |
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