Sag, Sabine Julia Maria and Menhart, Karin and Hitzenbichler, Florian and Schmid, Christof and Hofheinz, Frank and van den Hoff, Joerg and Maier, Lars Siegfried and Hellwig, Dirk and Grosse, Jirka and Sag, Can Martin (2023) ¹⁸F-FDG PET/CT-derived total lesion glycolysis predicts abscess formation in patients with surgically confirmed infective endocarditis: Results of a retrospective study at a tertiary center. JOURNAL OF NUCLEAR CARDIOLOGY, 30 (6). pp. 2400-2414. ISSN 1071-3581, 1532-6551
Full text not available from this repository. (Request a copy)Abstract
Background. Abnormal activity of F-18-FDG PET/CT is a major Duke criterion in the diagnostic work-up of infective prosthetic valve endocarditis (IE). We hypothesized that quantitative lesion assessment by F-18-FDG PET/CT-derived standard maximum uptake ratio (SURmax), metabolic volume (MV), and total lesion glycolysis (TLG) might be useful in distinct subgroups of IE patients (e.g. IE-related abscess formation). Methods. All patients (n = 27) hospitalized in our tertiary IE referral medical center from January 2014 to October 2018 with preoperatively performed F-18-FDG PET/CT and surgically confirmed IE were included into this retrospective analysis. Results. Patients with surgically confirmed abscess formation (n = 10) had significantly increased MV (by similar to fivefold) and TLG (by similar to sevenfold) as compared to patients without abscess (n = 17). Receiver operation characteristics (ROC) analyses demonstrated that TLG (calculated as MV x SURmean, i.e. TLG (SUR)) had the most favorable area under the ROC curve (0.841 [CI 0.659 to 1.000]) in predicting IE-related abscess formation. This resulted in a sensitivity of 80% and a specificity of 88% at a cut-off value of 14.14 mL for TLG (SUR). Conclusion. We suggest that F-18-FDG PET/CT-derived quantitative assessment of TLG (SUR) may provide a novel diagnostic tool in predicting endocarditis-associated abscess formation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROGNOSTIC VALUE; TOMOGRAPHY; PARAMETERS; F-18-FDG PET/CT; infective endocarditis; total lesion glycolysis; valve abscess |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Abteilung für Nuklearmedizin Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Feb 2024 06:59 |
| Last Modified: | 28 Feb 2024 06:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59138 |
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