Haas, Maximilian and Knobloch, Charlotte and Mayr, Roman and Gierth, Michael and Pickl, Christoph and Engelmann, Simon and Denzinger, Stefan and Burger, Maximilian and Breyer, Johannes and Holbach, Sonja (2023) Short-Term and Long-Term Morbidity after Radical Cystectomy in Patients with NMIBC and Comparison with MIBC: Identifying Risk Factors for Severe Short-Term Complications. UROLOGIA INTERNATIONALIS, 107 (3). pp. 246-256. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Introduction: RC represents a viable treatment option for certain NMIBC patients. However, studies investigating morbidity in the context of RC for NMIBC are scarce. The goal of the current study was to assess and compare morbidity after RC performed in patients with NMIBC and patients with MIBC and to identify risk factors for severe short-term complications. Methods: Medical records of 521 patients who underwent RC for bladder cancer were retrospectively reviewed. Patients were divided into patients with NMIBC and patients with MIBC. The groups were compared and risk factors for severe complications were identified. Results: RC for NMIBC was performed in 123 patients (23.6%). Histological upstaging was seen in 47 NMIBC patients (38.2%) and in 231 MIBC patients (58%, p < 0.001). OS was 29.8% and CSS was 15.5%. Both endpoints were higher for RC for MIBC (p < 0.001). More complications affecting the urinary diversion were seen with RC for NMIBC (p = 0.033) and more continent urinary diversions (p = 0.040) were performed in those patients. Obesity (p = 0.008), a higher ASA score (p = 0.004), and preoperative medical drug anticoagulation (p = 0.025) were risk factors for severe short-term morbidity after both, RC for NMIBC and for MIBC. Conclusion: Patients who underwent RC for NMIBC are exposed to a comparably high perioperative risk than patients with MIBC. RC seems to be a viable treatment option for certain NMIBC patients with a significant histological upstaging in both groups. In patients with obesity, a high ASA score, and with medical drug anticoagulation, the indication for surgery should be confirmed especially strict and possible treatment alternatives should be considered particularly thorough.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BLADDER-CANCER; UROTHELIAL CARCINOMA; URINARY-DIVERSION; PROGNOSTIC VALUE; MORTALITY; ASSOCIATION; COMORBIDITY; VALIDATION; OUTCOMES; AGE; Cystectomy; Non-muscle-invasive bladder cancer; Complications; Morbidity; Bladder carcinoma; Urothelial neoplasm |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Mar 2024 13:15 |
| Last Modified: | 08 Mar 2024 13:15 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59158 |
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