Spoerl, Steffen and Gerken, Michael and Fischer, Rene and Spoerl, Silvia and Kirschneck, Christian and Wolf, Stefanie and Taxis, Juergen and Ludwig, Nils and Biermann, Niklas and Reichert, Torsten E. and Spanier, Gerrit (2023) Statin Use Ameliorates Survival in Oral Squamous Cell Carcinoma-Data from a Population-Based Cohort Study Applying Propensity Score Matching. BIOMEDICINES, 11 (2): 369. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
The anti-cancer properties of statins have attracted much attention recently, but little is known about the prognostic role of statins in oral squamous cell carcinoma (OSCC). In a retrospective approach, we analyzed a population-based cohort of 602 OSCC patients with primary curative tumor resection to negative margins and concomitant neck dissection between 2005-2017. Long-term medication with statins was correlated with overall survival (OAS) as well as recurrence-free survival (RFS) using uni- and multivariable Cox regression. Additionally, propensity score matching was applied to adjust for confounders. Statin use was present in 96 patients (15.9%) at a median age of 65.7 years. Statin treatment correlated with ameliorated survival in multivariable Cox regression in the complete cohort (OAS: HR 0.664; 95% CI 0.467-0.945, p = 0.023; RFS: HR 0.662; 95% CI 0.476-0.920, p = 0.014) as well as matched-pair cohort of OSCC patients (OAS: HR 0.691; 95% CI 0.479-0.997, p = 0.048; RFS: HR 0.694; 95% CI 0.493-0.976, p = 0.036) when compared to patients not taking statins at time of diagnosis. These findings were even more pronounced by sub-group analysis in the matched-pair cohort (age < 70 years). These data indicate that statin use might ameliorate the oncological outcome in primarily resected OSCC patients, but prospective clinical trials are highly recommended.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOVASTATIN-INDUCED APOPTOSIS; CARDIOVASCULAR-DISEASE; CANCER-RISK; SENSITIVITY; PRAVASTATIN; HEAD; oral squamous cell carcinoma; OSCC; HNSCC; statin; hydroxymethylglutaryl CoA reductase inhibitor; cardiovascular disease; CVD; survival; propensity score matching; PSM |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 08:45 |
| Last Modified: | 09 Mar 2024 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59224 |
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