May, Matthias and Aziz, Atiqullah and Brookman-May, Sabine and Roghmann, Florian and Noldus, Joachim and Rink, Michael and Chun, Felix and Fisch, Margit and Novotny, Vladimir and Wirth, Manfred and Mayr, Roman and Pycha, Armin and Brisuda, Antonin and Volkmer, Bjoern and Stredele, Regina and Dechet, Christopher and Vallo, Stefan and Haferkamp, Axel and Schnabel, Marco and Denzinger, Stefan and Roigas, Jan and Stief, Christian G. and Gilfrich, Christian and Bastian, Patrick J. and Engel, Joerg B. and Burger, Maximilian and Fritsche, Hans-Martin (2015) Prognostic impact of infiltration of the vagina and/or uterus in women undergoing anterior pelvic exenteration for urothelial carcinoma of the bladder: results of a contemporary multicentre series. WORLD JOURNAL OF UROLOGY, 33 (3). pp. 343-350. ISSN 0724-4983, 1433-8726
Full text not available from this repository. (Request a copy)Abstract
To evaluate for the first time the prognostic significance of female invasive patterns in stage pT4a urothelial carcinoma of the bladder in a large series of women undergoing anterior pelvic exenteration. Our series comprised of 92 female patients in total of whom 87 with known invasion patterns were eligible for final analysis. Median follow-up for evaluation of cancer-specific mortality (CSM) was 38 months (interquartile ranges, 21-82 months). The impact on CSM was evaluated using multivariable Cox proportional-hazards regression analysis; predictive accuracy (PA) was assessed by receiver operating characteristic analysis. Vaginal invasion was noted in 33 patients (37.9 %; group VAG), uterine invasion in 20 patients (23 %; group UT), and infiltration of both vagina and uterus in 34 patients (39.1 %; group VAG + UT). Groups VAG and UT significantly differed from group VAG + UT with regard to the presence of positive soft tissue margins (STM) only. Five-year-cancer-specific survival probabilities in the groups VAG, UT, and VAG + UT were 21, 20, and 21 %, respectively (p = 0.955). On multivariable analysis, only STM status (HR = 2.02, p = 0.023) independently influenced CSM. C-indices of multivariable models for CSM with and without integration of invasive patterns were 0.570 and 0.567, respectively (PA gain 0.3 %, p = 0.526). Infiltration of the vagina, the uterus or both is associated with poor 5-year survival rates. With regard to CSM, no difference was detectable between patients with different invasion patterns, thus justifying further collectively including these invasive patterns as stage pT4a.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RADICAL CYSTECTOMY; ORGAN INVOLVEMENT; CANCER; Urothelial carcinoma; Bladder cancer; Radical cystectomy; Vaginal invasion; Uterine invasion; Prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2019 06:09 |
| Last Modified: | 26 Jul 2019 06:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5923 |
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