Ghosh, Indrajit and Shlapakov, Nikita and Karl, Tobias A. and Dueker, Jonas and Nikitin, Maksim and Burykina, Julia V. and Ananikov, Valentine P. and Koenig, Burkhard (2023) General cross-coupling reactions with adaptive dynamic homogeneous catalysis. NATURE, 619 (7968). pp. 87-93. ISSN 0028-0836, 1476-4687
Full text not available from this repository. (Request a copy)Abstract
Cross-coupling reactions are among the most important transformations in modern organic synthesis(1-3). Although the range of reported (het)aryl halides and nucleophile coupling partners is very large considering various protocols, the reaction conditions vary considerably between compound classes, necessitating renewed case-by-case optimization of the reaction conditions(4). Here we introduce adaptive dynamic homogeneous catalysis (AD-HoC) with nickel under visible-light-driven redox reaction conditions for general C(sp(2))-(hetero)atom coupling reactions. The self-adjustive nature of the catalytic system allowed the simple classification of dozens of various classes of nucleophiles in cross-coupling reactions. This is synthetically demonstrated in nine different bond-forming reactions (in this case, C(sp(2))-S, Se, N, P, B, O, C(sp(3), sp(2), sp), Si, Cl) with hundreds of synthetic examples under predictable reaction conditions. The catalytic reaction centre(s) and conditions differ from one another by the added nucleophile, or if required, a commercially available inexpensive amine base.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARYL |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Mar 2024 07:14 |
| Last Modified: | 01 Mar 2024 07:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59235 |
Actions (login required)
 |
View Item |
