von Breitenbuch, Philipp and Kurz, Bernadett and Wallner, Susanne and Zeman, Florian and Brochhausen, Christoph and Schlitt, Hans-Juergen and Schreml, Stephan (2023) Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal Cancer-First Results. JOURNAL OF CLINICAL MEDICINE, 12 (5): 1803. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Solid tumors have an altered metabolism with a so-called inside-out pH gradient (decreased pH(e) < increased pH(i)). This also signals back to tumor cells via proton-sensitive ion channels or G protein-coupled receptors (pH-GPCRs) to alter migration and proliferation. Nothing, however, is known about the expression of pH-GPCRs in the rare form of peritoneal carcinomatosis. Paraffin-embedded tissue samples of a series of 10 patients with peritoneal carcinomatosis of colorectal (including appendix) origin were used for immunohistochemistry to study the expression of GPR4, GPR65, GPR68, GPR132, and GPR151. GPR4 was just expressed weakly in 30% of samples and expression was significantly reduced as compared to GPR56, GPR132, and GPR151. Furthermore, GPR68 was only expressed in 60% of tumors and showed significantly reduced expression as compared to GPR65 and GPR151. This is the first study on pH-GPCRs in peritoneal carcinomatosis, which shows lower expression of GPR4 and GPR68 as compared to other pH-GPCRs in this type of cancer. It may give rise to future therapies targeting either the TME or these GPCRs directly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-COUPLED RECEPTOR; TUMOR-GROWTH; TDAG8; MIGRATION; GENE; OVEREXPRESSION; PROLIFERATION; INVOLVEMENT; METASTASIS; INHIBITION; colorectal; peritoneal carcinomatosis; tumor microenvironment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 08:51 |
| Last Modified: | 09 Mar 2024 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59240 |
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