Anthofer, Judith Maria and Steib, Kathrin and Fellner, Claudia and Lange, Max and Brawanski, Alexander and Schlaier, Juergen (2015) DTI-based deterministic fibre tracking of the medial forebrain bundle. ACTA NEUROCHIRURGICA, 157 (3). pp. 469-477. ISSN 0001-6268, 0942-0940
Full text not available from this repository. (Request a copy)Abstract
Deep brain stimulation (DBS) of the medial forebrain bundle (MFB) was reported to reduce symptoms in psychiatric disorders. The aim of our study was to find standardised parameters for diffusion tensor imaging (DTI) based fibre tracking to reliably visualise the MFB. Twenty-two cerebral hemispheres in 11 patients were investigated. Three different regions of interest (ROIs) were defined as seed regions for fibre tracking: the ipsilateral and contralateral superior cerebellar peduncle (SCP) and the nucleus raphe dorsalis (NRD). From each seed region the fibres were followed separately through the ventral tegmental area (VTA = second ROI) and their further courses and volumina were documented and compared. Minimal fibre length was set at 30 mm and the FA threshold at 0.12. The fibre tracts starting in seed regions in the ipsilateral SCP and the NRD follow a similar course along the lateral wall of the third ventricle (hypothalamus) and the anterior limb of the internal capsule (ALIC) to inferior fronto-medial brain areas. These fibres are in accordance with the course of the MFB as described in various anatomical atlases. Consistently, a branch leaves the main fibre tract laterally to take a course through the capsula externa to the temporo-parietal cortex. Fibre tracts starting from the contralateral SCP follow a more superior and lateral course, including the dentato-rubro-thalamic and the pyramidal tract. Deterministic fibre tracking with standardised ROIs provides constant and reproducible delineations of the medial forebrain bundle. Its visualisation might help to adjust targeting in DBS for psychiatric disorders.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEEP BRAIN-STIMULATION; OBSESSIVE-COMPULSIVE-DISORDER; TREATMENT-RESISTANT DEPRESSION; NUCLEUS-ACCUMBENS; MAJOR DEPRESSION; ELECTRICAL-STIMULATION; PARKINSONS-DISEASE; OUTCOMES; STRIATUM; ATLAS; Deep brain stimulation (DBS); Diffusion tensor imaging (DTI); Medial forebrain bundle (MFB); Major depression (MD) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurochirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jul 2019 06:19 |
| Last Modified: | 26 Jul 2019 06:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5925 |
Actions (login required)
 |
View Item |
