Jagasia, Madan H. and Greinix, Hildegard T. and Arora, Mukta and Williams, Kirsten M. and Wolff, Daniel and Cowen, Edward W. and Palmer, Jeanne and Weisdorf, Daniel and Treister, Nathaniel S. and Cheng, Guang-Shing and Kerr, Holly and Stratton, Pamela and Duarte, Rafael F. and McDonald, George B. and Inamoto, Yoshihiro and Vigorito, Afonso and Arai, Sally and Datiles, Manuel B. and Jacobsohn, David and Heller, Theo and Kitko, Carrie L. and Mitchell, Sandra A. and Martin, Paul J. and Shulman, Howard and Wu, Roy S. and Cutler, Corey S. and Vogelsang, Georgia B. and Lee, Stephanie J. and Pavletic, Steven Z. and Flowers, Mary E. D. (2015) National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group Report. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21 (3). pp. 389-401. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies. (C) 2015 American Society for Blood and Marrow Transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; BONE-MARROW-TRANSPLANTATION; CHRONIC GVHD CONSORTIUM; RISK-FACTORS; NONRELAPSE MORTALITY; SURVIVAL; SEVERITY; OUTCOMES; SCORE; ORGAN; Chronic graft-versus-host disease; National Institutes of Health; Diagnosis; Staging |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2019 09:00 |
| Last Modified: | 24 Jul 2019 09:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5926 |
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