Morgenstern, Eva and Kretz, Markus (2023) The human long non-coding RNA LINC00941 and its modes of action in health and disease. BIOLOGICAL CHEMISTRY, 404 (11-12). pp. 1025-1036. ISSN 1431-6730, 1437-4315
Full text not available from this repository. (Request a copy)Abstract
Long non-coding RNAs have gained attention in recent years as they were shown to play crucial roles in the regulation of cellular processes, but the understanding of the exact mechanisms is still incomplete in most cases. This is also true for long non-coding RNA LINC00941, which was recently found to be highly upregulated in various types of cancer influencing cell proliferation and metastasis. Initial studies could not elucidate the mode of action to understand the role and real impact of LINC00941 in tissue homeostasis and cancer development. However, recent analyses have demonstrated multiple potential modes of action of LINC00941 influencing the functionality of various cancer cell types. Correspondingly, LINC00941 was proposed to be involved in regulation of mRNA transcription and modulation of protein stability, respectively. In addition, several experimental approaches suggest a function of LINC00941 as competitive endogenous RNA, thus acting in a post-transcriptional regulatory fashion. This review summarizes our recent knowledge about the mechanisms of action of LINC00941 elucidated so far and discusses its putative role in miRNA sequestering processes. In addition, the functional role of LINC00941 in regulating human keratinocytes is discussed to also highlight its role in normal tissue homeostasis tissue aside from its involvement in cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | EPIDERMAL DIFFERENTIATION COMPLEX; PROMOTES PROLIFERATION; PANCREATIC-CANCER; CERNA HYPOTHESIS; EXPRESSION; PROTEINS; LNCRNAS; cancer; ceRNA; post-transcriptional regulation; protein-RNA interaction; RNA-RNA interaction; transcriptional regulation |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie I > Prof. Dr. Gunter Meister |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 08:51 |
| Last Modified: | 05 Mar 2024 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59267 |
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