Piso, Pompiliu and Arnold, Dirk and Glockzin, Gabriel (2015) Challenges in the multidisciplinary management of stage IV colon and rectal cancer. EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY, 9 (3). pp. 317-326. ISSN 1747-4124, 1747-4132
Full text not available from this repository. (Request a copy)Abstract
Colorectal metastases still represent a challenge to all oncologists despite progresses achieved by improved resectability, systemic chemotherapy and targeted therapies. In particular in patients with oligo-metastases, the role of surgical resections has been redefined. Resection is the most effective treatment method for liver metastases performed with curative intent; however, primary rate of resectability is low. Several methods to increase resectability have been developed: conversion chemotherapy, portal vein embolization, two-stage resections, vascular reconstruction of the liver veins, combination of resection and intraoperative ablation. Liver resections can be performed at present with low mortality. Patients with isolated peritoneal metastases, no extra-abdominal disease, low volume tumor and complete surgical cytoreduction do benefit from surgery and hyperthermic intraperitoneal chemotherapy. Several national guidelines recommend multimodality treatment for highly selected patients. The management of stage IV colorectal cancer includes several disciplines with focus on resection. A multidisciplinary evaluation of all patients is of crucial importance to define the treatment sequence and individual strategies for each patient.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY; COLORECTAL LIVER METASTASES; PERITONEAL CARCINOMATOSIS; CYTOREDUCTIVE SURGERY; SYSTEMIC CHEMOTHERAPY; HEPATIC RESECTION; CURATIVE APPROACH; RANDOMIZED-TRIAL; PHASE-II; RECURRENCE; ALPPS; HIPEC; liver metastases; peritoneal carcinomatosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Aug 2020 09:34 |
| Last Modified: | 14 Aug 2020 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5927 |
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