Rink, Simone and Baeumner, Antje J. (2023) Progression of Paper-Based Point-of-Care Testing toward Being an Indispensable Diagnostic Tool in Future Healthcare. ANALYTICAL CHEMISTRY, 95 (3). pp. 1785-1793. ISSN 0003-2700, 1520-6882
Full text not available from this repository. (Request a copy)Abstract
Point-of-care (POC) diagnostics in particular focuses on the timely identification of harmful conditions close to the patients' needs. For future healthcare these diagnostics could be an invaluable tool especially in a digitalized or telemedicine-based system. However, while paper-based POC tests, with the most prominent example being the lateral flow assay (LFA), have been especially successful due to their simplicity and timely response, the COVID-19 pandemic highlighted their limitations, such as low sensitivity and ambiguous responses. This perspective discusses strategies that are currently being pursued to evolve such paper-based POC tests toward a superior diagnostic tool that provides high sensitivities, objective result interpretation, and multiplexing options. Here, we pinpoint the challenges with respect to (i) measurability and (ii) public applicability, exemplified with select cases. Furthermore, we highlight promising endeavors focused on (iii) increasing the sensitivity, (iv) multiplexing capability, and (v) objective evaluation to also ready the technology for integration with machine learning into digital diagnostics and telemedicine. The status quo in academic research and industry is outlined, and the likely highly relevant role of paper-based POC tests in future healthcare is suggested.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LATERAL FLOW ASSAY; QUANTITATIVE DETECTION; SENSITIVITY; MULTIPLEX; IMMUNOASSAY; BIOMARKERS; PLATFORM; DEVICES; LEAD |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 09:14 |
| Last Modified: | 05 Mar 2024 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59289 |
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