Peterhoff, David and Wiegrebe, Simon and Einhauser, Sebastian and Patt, Arisha J. and Beileke, Stephanie and Guenther, Felix and Steininger, Philipp and Niller, Hans H. and Burkhardt, Ralph and Kuechenhoff, Helmut and Gefeller, Olaf and Ueberla, Klaus and Heid, Iris M. and Wagner, Ralf (2023) Population-based study of the durability of humoral immunity after SARS-CoV-2 infection. FRONTIERS IN IMMUNOLOGY, 14: 1242536. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
SARS-CoV-2 antibody quantity and quality are key markers of humoral immunity. However, there is substantial uncertainty about their durability. We investigated levels and temporal change of SARS-CoV-2 antibody quantity and quality. We analyzed sera (8 binding, 4 avidity assays for spike-(S-)protein and nucleocapsid-(N-)protein; neutralization) from 211 seropositive unvaccinated participants, from the population-based longitudinal TiKoCo study, at three time points within one year after infection with the ancestral SARS-CoV-2 virus. We found a significant decline of neutralization titers and binding antibody levels in most assays (linear mixed regression model, p<0.01). S-specific serum avidity increased markedly over time, in contrast to N-specific. Binding antibody levels were higher in older versus younger participants - a difference that disappeared for the asymptomatic-infected. We found stronger antibody decline in men versus women and lower binding and avidity levels in current versus never-smokers. Our comprehensive longitudinal analyses across 13 antibody assays suggest decreased neutralization-based protection and prolonged affinity maturation within one year after infection.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTI-SARS-COV-2 ANTIBODY; SEROPREVALENCE; COVID-19; SARS-CoV-2; COVID-19; longitudinal; durability; population-based; antibody; neutralization; avidity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 11:56 |
| Last Modified: | 09 Mar 2024 11:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59328 |
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