Kurz, Bernadett and Michael, Hannah Philine and Foerch, Antonia and Wallner, Susanne and Zeman, Florian and Decking, Sonja-Maria and Ugele, Ines and Hintschich, Constantin and Haubner, Frank and Ettl, Tobias and Renner, Kathrin and Brochhausen, Christoph and Schreml, Stephan (2023) Expression of pH-Sensitive TRPC4 in Common Skin Tumors. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (2): 1037. ISSN , 1422-0067
Full text not available from this repository. (Request a copy)Abstract
TRPCs (transient receptor potential classical or cation channels) play a crucial role in tumor biology, especially in the Ca2+ homeostasis in cancer cells. TRPC4 is a pH-sensitive member of this family of proteins. As solid tumors exhibit an inversed pH-gradient with lowered extracellular and increased intracellular pH, both contributing to tumor progression, TRPC4 might be a signaling molecule in the altered tumor microenvironment. This is the first study to investigate the expression profiles of TRPC4 in common skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM) and nevus cell nevi (NCN). We found that all SCCs, NCNs, and MMs show positive TRPC4-expression, while BCCs do only in about half of the analyzed samples. These data render TRPC4 an immunohistochemical marker to distinguish SCC and BCC, and this also gives rise to future studies investigating the role of TRPC4 in tumor progression, and especially metastasis as BCCs very rarely spread and are mostly negative for TRPC4.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-PROLIFERATION; CHANNELS; CALCIUM; RECEPTOR; DIFFERENTIATION; TRPC4; skin tumors; melanoma; squamous cell carcinoma; basal cell carcinoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 13:45 |
| Last Modified: | 09 Mar 2024 13:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59384 |
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