Verloh, Niklas and Bartulos, Carolina Rio and Utpatel, Kirsten and Brennfleck, Frank and Goetz, Andrea and Schicho, Andreas and Fellner, Claudia and Nickel, Dominik and Zeman, Florian and Steinmann, Johannes F. and Uller, Wibke and Stroszczynski, Christian and Schlitt, Hans-Juergen and Wiggermann, Phillip and Haimerl, Michael (2023) Volume-Assisted Estimation of Remnant Liver Function Based on Gd-EOB-DTPA Enhanced MR Relaxometry: A Prospective Observational Trial. DIAGNOSTICS, 13 (18): 3014. ISSN , 2075-4418
Full text not available from this repository. (Request a copy)Abstract
In the context of liver surgery, predicting postoperative liver dysfunction is essential. This study explored the potential of preoperative liver function assessment by MRI for predicting postoperative liver dysfunction and compared these results with the established indocyanine green (ICG) clearance test. This prospective study included patients undergoing liver resection with preoperative MRI planning. Liver function was quantified using T1 relaxometry and correlated with established liver function scores. The analysis revealed an improved model for predicting postoperative liver dysfunction, exhibiting an accuracy (ACC) of 0.79, surpassing the 0.70 of the preoperative ICG test, alongside a higher area under the curve (0.75). Notably, the proposed model also successfully predicted all cases of liver failure and showed potential in predicting liver synthesis dysfunction (ACC 0.78). This model showed promise in patient survival rates with a Hazard ratio of 0.87, underscoring its potential as a valuable tool for preoperative evaluation. The findings imply that MRI-based assessment of liver function can provide significant benefits in the early identification and management of patients at risk for postoperative liver dysfunction.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T1 RELAXATION-TIME; HEPATIC RESECTION; CONTRAST AGENT; FAILURE; PREDICTION; liver resection; liver dysfunction; postoperative remnant liver function; small for size syndrome; magnetic resonance imaging (MRI); gadoxetic acid-enhanced MRI (Gd-EOB-DTPA) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 14:31 |
| Last Modified: | 09 Mar 2024 14:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59413 |
Actions (login required)
 |
View Item |
