Tafelmeier, Maria and Blagoeva, Verka-Georgieva and Trum, Maximilian and Hegner, Philipp and Floerchinger, Bernhard and Camboni, Daniele and Creutzenberg, Marcus and Zeman, Florian and Schmid, Christof and Maier, Lars Siegfried and Wagner, Stefan and Linz, Dominik and Baumert, Mathias and Arzt, Michael (2023) Predictors of Nocturnal Hypoxemic Burden in Patients Undergoing Elective Coronary Artery Bypass Grafting Surgery. BIOMEDICINES, 11 (10): 2665. ISSN , 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Background: Nocturnal hypoxemia has been linked to increased cardiovascular morbidity and mortality. Several common diseases, such as sleep-disordered breathing (SDB), heart failure (HF), obesity, and pulmonary disease, coincide with an elevated nocturnal hypoxemic burden with and without repetitive desaturations. Research question: This study aimed to evaluate the association of relevant common diseases with distinctive metrics of nocturnal hypoxemic burden with and without repetitive desaturations in patients undergoing coronary artery bypass grafting surgery. Study design and methods: In this subanalysis of the prospective observational study, CONSIDER-AF (NCT02877745) portable SDB monitoring was performed on 429 patients with severe coronary artery disease the night before cardiac surgery. Pulse oximetry was used to determine nocturnal hypoxemic burden, as defined by total recording time spent with oxygen saturation levels < 90% (T90). T90 was further characterized as T90 due to intermittent hypoxemia (T90(desaturation)) and T90 due to nonspecific and noncyclic SpO(2)-drifts (T90(non-specific)). Results: Multivariable linear regression analysis identified SDB (apnea-hypopnea-index >= 15/h; B [95% CI]: 6.5 [0.4; 12.5], p = 0.036), obesity (8.2 [2.5; 13.9], p = 0.005), and mild-to-moderate chronic obstructive pulmonary disease (COPD, 16.7 [8.5; 25.0], p < 0.001) as significant predictors of an increased nocturnal hypoxemic burden. Diseases such as SDB, obesity and HF were significantly associated with elevated T90(desaturation). In contrast, obesity and mild-to-moderate COPD were significant modulators of T90(non-specific). Interpretation: SDB and leading causes for SDB, such as obesity and HF, are associated with an increased nocturnal hypoxemic burden with repetitive desaturations. Potential causes for hypoventilation syndromes, such as obesity and mild-to-moderate COPD, are linked to an increased hypoxemic burden without repetitive desaturations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL SLEEP-APNEA; HEART-FAILURE; FLUID SHIFT; OBESITY; COPD; DESATURATION; MORTALITY; T90; nocturnal hypoxemia; sleep apnea; heart failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Anästhesiologie Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 09 Mar 2024 16:00 |
| Last Modified: | 09 Mar 2024 16:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59442 |
Actions (login required)
 |
View Item |
