Oliinyk, Dmytro and Eigenberger, Andreas and Felthaus, Oliver and Haerteis, Silke and Prantl, Lukas (2023) Chorioallantoic Membrane Assay at the Cross-Roads of Adipose-Tissue-Derived Stem Cell Research. CELLS, 12 (4): 592. ISSN 2073-4409
Full text not available from this repository. (Request a copy)Abstract
With a history of more than 100 years of different applications in various scientific fields, the chicken chorioallantoic membrane (CAM) assay has proven itself to be an exceptional scientific model that meets the requirements of the replacement, reduction, and refinement principle (3R principle). As one of three extraembryonic avian membranes, the CAM is responsible for fetal respiration, metabolism, and protection. The model provides a unique constellation of immunological, vascular, and extracellular properties while being affordable and reliable at the same time. It can be utilized for research purposes in cancer biology, angiogenesis, virology, and toxicology and has recently been used for biochemistry, pharmaceutical research, and stem cell biology. Stem cells and, in particular, mesenchymal stem cells derived from adipose tissue (ADSCs) are emerging subjects for novel therapeutic strategies in the fields of tissue regeneration and personalized medicine. Because of their easy accessibility, differentiation profile, immunomodulatory properties, and cytokine repertoire, ADSCs have already been established for different preclinical applications in the files mentioned above. In this review, we aim to highlight and identify some of the cross-sections for the potential utilization of the CAM model for ADSC studies with a focus on wound healing and tissue engineering, as well as oncological research, e.g., sarcomas. Hereby, the focus lies on the combination of existing evidence and experience of such intersections with a potential utilization of the CAM model for further research on ADSCs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPROVE POSTNATAL NEOVASCULARIZATION; CHICK-EMBRYO; IN-VITRO; ENDOTHELIAL-CELLS; EXTRACELLULAR VESICLES; STROMAL/STEM CELLS; OSTEOGENIC DIFFERENTIATION; ANGIOGENIC ACTIVITY; GROWTH-FACTOR; MODEL; adipose-derived stem cells; mesenchymal stem cells; chorioallantoic membrane; CAM assay; wound healing; tissue regeneration; tissue engineering; scaffolds; biocompatibility |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2024 11:03 |
| Last Modified: | 13 Mar 2024 06:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59454 |
Actions (login required)
 |
View Item |
