Morsczeck, Christian and De Pellegrin, Michela and Reck, Anja and Reichert, Torsten E. (2023) Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation. MDPI, BASEL.
Full text not available from this repository. (Request a copy)Abstract
When research on osteogenic differentiation in dental follicle cells (DFCs) began, projects focused on bone morphogenetic protein (BMP) signaling. The BMP pathway induces the transcription factor DLX3, whichh in turn induces the BMP signaling pathway via a positive feedback mechanism. However, this BMP2/DLX3 signaling pathway only seems to support the early phase of osteogenic differentiation, since simultaneous induction of BMP2 or DLX3 does not further promote differentiation. Recent data showed that inhibition of classical protein kinase C (PKCs) supports the mineralization of DFCs and that osteogenic differentiation is sensitive to changes in signaling pathways, such as protein kinase B (PKB), also known as AKT. Small changes in the lipidome seem to confirm the participation of AKT and PKC in osteogenic differentiation. In addition, metabolic processes, such as fatty acid biosynthesis, oxidative phosphorylation, or glycolysis, are essential for the osteogenic differentiation of DFCs. This review article attempts not only to bring the various factors into a coherent picture of osteogenic differentiation in DFCs, but also to relate them to recent developments in other types of osteogenic progenitor cells.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; NF-KAPPA-B; PROTEIN-KINASE-C; BONE-MARROW; ALKALINE-PHOSPHATASE; IN-VITRO; OSTEOBLAST DIFFERENTIATION; PATHWAY SUSTAINS; PRECURSOR CELLS; ACTIVATION; dental stem cells; lipidomics; metabolism; protein kinase C |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2024 14:50 |
| Last Modified: | 12 Mar 2024 14:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59487 |
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