Mamilos, Andreas and Winter, Lina and Schmitt, Volker H. and Barsch, Friedrich and Grevenstein, David and Wagner, Willi and Babel, Maximilian and Keller, Karsten and Schmitt, Christine and Guertler, Florian and Schreml, Stephan and Niedermair, Tanja and Rupp, Markus and Alt, Volker and Brochhausen, Christoph (2023) Macrophages: From Simple Phagocyte to an Integrative Regulatory Cell for Inflammation and Tissue Regeneration-A Review of the Literature. CELLS, 12 (2): 276. ISSN 2073-4409
Full text not available from this repository. (Request a copy)Abstract
The understanding of macrophages and their pathophysiological role has dramatically changed within the last decades. Macrophages represent a very interesting cell type with regard to biomaterial-based tissue engineering and regeneration. In this context, macrophages play a crucial role in the biocompatibility and degradation of implanted biomaterials. Furthermore, a better understanding of the functionality of macrophages opens perspectives for potential guidance and modulation to turn inflammation into regeneration. Such knowledge may help to improve not only the biocompatibility of scaffold materials but also the integration, maturation, and preservation of scaffold-cell constructs or induce regeneration. Nowadays, macrophages are classified into two subpopulations, the classically activated macrophages (M1 macrophages) with pro-inflammatory properties and the alternatively activated macrophages (M2 macrophages) with anti-inflammatory properties. The present narrative review gives an overview of the different functions of macrophages and summarizes the recent state of knowledge regarding different types of macrophages and their functions, with special emphasis on tissue engineering and tissue regeneration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-ASSOCIATED MACROPHAGES; ALTERNATIVELY ACTIVATED MACROPHAGES; MULTINUCLEATED GIANT-CELLS; TOLL-LIKE RECEPTORS; NITRIC-OXIDE; NECROSIS-FACTOR; IN-VIVO; MATRIX METALLOPROTEINASES; HEMATOPOIETIC STEM; IMMUNE-RESPONSES; macrophage; plasticity; monocytes; inflammation; tissue regeneration; biomaterials; M1-macrophages; M2-macrophages |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2024 10:02 |
| Last Modified: | 19 Mar 2024 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59583 |
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