Peter, Hannah L. and Giglberger, Marina and Streit, Fabian and Frank, Josef and Kreuzpointner, Ludwig and Rietschel, Marcella and Kudielka, Brigitte M. and Wuest, Stefan (2023) Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period. GENES BRAIN AND BEHAVIOR, 22 (6). ISSN 1601-1848, 1601-183X
Full text not available from this repository.Abstract
Genetic factors contribute significantly to interindividual differences in the susceptibility to stress-related disorders. As stress can also be conceptualized as environmental exposure, controlled gene-environment interaction (GxE) studies with an in-depth phenotyping may help to unravel mechanisms underlying the interplay between genetic factors and stress. In a prospective-longitudinal quasi-experimental study, we investigated whether polygenic scores (PGS) for depression (DEP-PGS) and neuroticism (NEU-PGS), respectively, were associated with responses to chronic stress in daily life. We examined law students (n = 432) over 13 months. Participants in the stress group experienced a long-lasting stress phase, namely the preparation for the first state examination for law students. The control group consisted of law students without particular stress exposure. In the present manuscript, we analyzed perceived stress levels assessed at high frequency and in an ecologically valid manner by ambulatory assessments as well as depression symptoms and two parameters of the cortisol awakening response. The latter was only assessed in a subsample (n = 196). No associations between the DEP-PGS and stress-related variables were found. However, for the NEU-PGS we found a significant GxE effect. Only in individuals experiencing academic stress a higher PGS for neuroticism predicted stronger increases of perceived stress levels until the exam. At baseline, a higher NEU-PGS was associated with higher perceived stress levels in both groups. Despite the small sample size, we provide preliminary evidence that the genetic disposition for neuroticism is associated with stress level increases in daily life during a long-lasting stress period. In the LawSTRESS project, a study with a prospective-longitudinal quasi-experimental design, German law students experiencing (stress group) or not experiencing (control group) a long-lasting stress phase were examined. We analyzed whether polygenic scores (PGS) for depression and neuroticism, respectively, were associated with perceived stress levels in daily life. For the neuroticism PGS we found a significant GxE effect; only in the stress group a higher PGS predicted stronger increases of perceived stress levels over 13 months.image
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-ENVIRONMENT INTERACTIONS; SALIVARY CORTISOL; MAJOR DEPRESSION; UNPUBLISHED DATA; WORKING HOURS; RISK; PERSONALITY; METAANALYSIS; DISORDERS; SYMPTOMS; ambulatory assessment; chronic stress; cortisol awakening response; depression; neuroticism; polygenic scores; quasi-experimental design |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Human Sciences > Institut für Psychologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2024 13:44 |
| Last Modified: | 10 Mar 2024 13:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59589 |
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