Prei, Kilian and Kanig, Carolina and Osnabruegge, Mirja and Langguth, Berthold and Mack, Wolfgang and Abdelnaim, Mohamed and Schecklmann, Martin and Schoisswohl, Stefan (2023) Limited evidence for reliability of low and high frequency rTMS over the motor cortex. BRAIN RESEARCH, 1820: 148534. ISSN 0006-8993, 1872-6240
Full text not available from this repository. (Request a copy)Abstract
Objective: The aim of this study was to investigate the reliability of low-frequency and high-frequency repetitive transcranial magnetic stimulation (rTMS) on healthy individuals over the motor cortex. A secondary outcome was the assessment if low-frequency rTMS results in inhibition and high-frequency rTMS results in facilitation. Methods: In this experiment, 30 healthy participants received on four consecutive days one session each with application of 1 Hz or 20 Hz rTMS over the left motor cortex. 1 Hz and 20 Hz were applied in alternating order, whereby the starting frequency was randomized. Motor evoked potentials (MEPs) were measured before and after each session. Reliability measures were intraclass and Pearson's correlation coefficient (ICC and r). Results: ICCs and r values were low to moderate. Notably, within subgroups of less confounded measures, we found good r values for 20 Hz rTMS. The group-level analysis did not demonstrate a clear low-frequency inhibition and high-frequency facilitation pattern. At the single-subject level, only one participant exhibited significant changes consistent with the expected pattern, with concurrent decreases in MEPs following 1 Hz sessions and increases following 20 Hz sessions. Conclusion: The investigated neuromodulatory protocols show low to moderate reliability. Results are questioning the low-frequency inhibition and high-frequency facilitation pattern. Significance: Methodological improvements for the usage of rTMS are necessary to increase validity and reliability of non-invasive brain stimulation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST-STIMULATION; CORTICOSPINAL EXCITABILITY; CORTICAL EXCITABILITY; INTERINDIVIDUAL VARIABILITY; SILENT PERIOD; MODULATION; PLASTICITY; BRAIN; STATE; Cortical excitability; Motor evoked potential (MEP); Repetitive transcranial magnetic stimulation; (rTMS); Test-retest reliability; Variability |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:48 |
| Last Modified: | 30 Jan 2024 10:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59597 |
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