Ritu, and Kolb, Daniel and Jain, Nidhi and Koenig, Burkhard (2023) Synthesis of Linear Enamides and Enecarbamates <i>via</i> Photoredox Acceptorless Dehydrogenation. ADVANCED SYNTHESIS & CATALYSIS, 365 (4). pp. 605-611. ISSN 1615-4150, 1615-4169
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In recent years, several methods for the direct desaturation of aliphatic compounds have been developed, facilitated by the unique combination of photoredox and transition-metal catalysis. Hereby, alkenes with high functionalization potential can be prepared in a straightforward fashion. We adapted a previously reported system involving tetrabutylammonium decatungstate (TBADT) as hydrogen atom transfer (HAT) agent and a cobaloxime co-catalyst for dihydrogen evolution for the dehydrogenative preparation of linear enamides and enecarbamates from saturated precursors. The substrate scope includes several natural products and drug derivatives. The reaction does not require noble metal catalysts, exhibits short reaction times compared to previous methods and is suitable for the late-stage functionalization of drug derivatives.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-H ELIMINATION; ATOM TRANSFER HAT; DECATUNGSTATE ANION; HOMOGENEOUS SYSTEM; HYDROGEN EVOLUTION; N-HETEROCYCLES; DESATURATION; DERIVATIVES; ACTIVATION; CATALYSIS; Photocatalysis; Dehydrogenation; HAT Catalysis; beta-hydride elimination; Enamide |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2024 14:24 |
| Last Modified: | 10 Mar 2024 14:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59603 |
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