Fellner, Claudia and Nickel, Marcel Dominik and Kannengiesser, Stephan and Verloh, Niklas and Stroszczynski, Christian and Haimerl, Michael and Luerken, Lukas (2023) Water-Fat Separated T1 Mapping in the Liver and Correlation to Hepatic Fat Fraction. DIAGNOSTICS, 13 (2): 201. ISSN , 2075-4418
Full text not available from this repository. (Request a copy)Abstract
(1) Background: T1 mapping in magnetic resonance imaging (MRI) of the liver has been proposed to estimate liver function or to detect the stage of liver disease, among others. Thus far, the impact of intrahepatic fat on T1 quantification has only been sparsely discussed. Therefore, the aim of this study was to evaluate the potential of water-fat separated T1 mapping of the liver. (2) Methods: A total of 386 patients underwent MRI of the liver at 3 T. In addition to routine imaging techniques, a 3D variable flip angle (VFA) gradient echo technique combined with a two-point Dixon method was acquired to calculate T1 maps from an in-phase (T1_in) and water-only (T1_W) signal. The results were correlated with proton density fat fraction using multi-echo 3D gradient echo imaging (PDFF) and multi-echo single voxel spectroscopy (PDFF_MRS). Using T1_in and T1_W, a novel parameter FF_T1 was defined and compared with PDFF and PDFF_MRS. Furthermore, the value of retrospectively calculated T1_W (T1_W_calc) based on T1_in and PDFF was assessed. Wilcoxon test, Pearson correlation coefficient and Bland-Altman analysis were applied as statistical tools. (3) Results: T1_in was significantly shorter than T1_W and the difference of both T1 values was correlated with PDFF (R = 0.890). FF_T1 was significantly correlated with PDFF (R = 0.930) and PDFF_MRS (R = 0.922) and yielded only minor bias compared to both established PDFF methods (0.78 and 0.21). T1_W and T1_W_calc were also significantly correlated (R = 0.986). (4) Conclusion: T1_W acquired with a water-fat separated VFA technique allows to minimize the influence of fat on liver T1. Alternatively, T1_W can be estimated retrospectively from T1_in and PDFF, if a Dixon technique is not available for T1 mapping.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GD-EOB-DTPA; RELAXATION-TIME; MR RELAXOMETRY; ENHANCED MRI; T-1; QUANTIFICATION; STEATOSIS; CIRRHOSIS; DISEASES; VOLUME; liver; quantitative magnetic resonance imaging; T1 mapping; Dixon |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2024 15:02 |
| Last Modified: | 10 Mar 2024 15:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59619 |
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