Straub, Rainer H. and Pongratz, Georg and Buttgereit, Frank and Gaber, Timo (2023) Energy metabolism of the immune system Consequences in chronic inflammation. ZEITSCHRIFT FUR RHEUMATOLOGIE, 82. pp. 479-490. ISSN 0340-1855, 1435-1250
Full text not available from this repository. (Request a copy)Abstract
Background: Energy is the currency of life. The systemic and intracellular energy metabolism plays an essential role for the energy supply of the resting and activated immune system and this also applies to chronic inflammatory diseases.Objective: This presentation examines both components of the systemic and cellular energy metabolism in health and chronic inflammation.Material and methods: A literature search was conducted using PubMed, Embase and the Cochrane Library. The information is presented in the form of a narrative review.Results: A chronically activated immune system acquires large amounts of energy-rich substrates that are lost for other functions of the body. In particular, the immune system and the brain are in competition. The consequences of this competition are many known diseases, such as fatigue, anxiety, depression, anorexia, sleep problems, sarcopenia, osteoporosis, insulin resistance, hypertension and others. The permanent change in the brain causes long-term alterations that stimulate disease sequelae even after disease remission. In the intracellular energy supply, chronic inflammation typically involves a conversion to glycolysis (to lactate, which has its own regulatory functions) and the pentose phosphate pathway in disorders of mitochondrial function. The chronic changes in immune cells of patients with rheumatoid arthritis (RA) lead to a disruption of the citric acid cycle (Krebs cycle). The hypoxic situation in the inflamed tissue stimulates many alterations. A differentiation is made between effector functions and regulatory functions of immune cells.Conclusion: Based on the energy changes mentioned, novel treatment suggestions can be made in addition to those already known in energy metabolism.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELL RESPONSES; SYNOVIAL-FLUID LIPIDS; RHEUMATOID-ARTHRITIS; HYPOXIA; BRAIN; DYSFUNCTION; BIOENERGETICS; ACTIVATION; GENERATION; INHIBITION; Energy metabolism of the body; Cellular energy metabolism; Rheumatic disease; Hypoxia; Brain |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2024 09:39 |
| Last Modified: | 19 Mar 2024 09:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59623 |
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