Bohley, Marilena and Dillinger, Andrea E. and Braunger, Barbara M. and Tamm, Ernst R. and Goepferich, Achim (2023) Intravenous injection of cyclosporin A loaded lipid nanocapsules fights inflammation and immune system activation in a mouse model of diabetic retinopathy. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 13 (11). pp. 2807-2818. ISSN 2190-393X, 2190-3948
Full text not available from this repository. (Request a copy)Abstract
Inflammation and immune system activation are key pathologic events in the onset and escalation of diabetic retinopathy (DR). Both are driven by cytokines and complement originating from the retinal pigment epithelium (RPE). Despite the RPE's pivotal role, there is no therapeutic tool to specifically interfere with the RPE-related pathomechanism. A therapy that addresses RPE cells and counteracts inflammation and immune response would be of paramount value for the early treatment of DR, where currently are no specific therapies available. Here, we utilized lipoprotein-mimetic lipid nanocapsules to deliver the anti-inflammatory and immunosuppressive drug cyclosporin A (CsA) to RPE cells. Using a mouse model of DR that mirrors all pathologic aspects of human DR, we demonstrate that intravenously applied CsA-loaded lipid nanocapsules comprehensively counteract inflammation and immune system activation. One single injection suppressed the expression of pro-inflammatory cytokines, dampened macrophage infiltration, and prevented macrophage and microglia activation in eyes with DR. This work shows that CsA-loaded lipid nanocapsules can offer new avenues for the treatment of DR.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MANAGEMENT; PANCREAS; Diabetic retinopathy; Intravenous nanotherapy; RPE; Drug delivery; Lipid nanocapsules; Cyclosporin A |
| Subjects: | 600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy |
| Divisions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 10 Mar 2024 15:20 |
| Last Modified: | 10 Mar 2024 15:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59633 |
Actions (login required)
 |
View Item |
