Raeth, Ulrich and Mester, Patricia and Schwarz, Herbert and Schmid, Stephan and Mueller, Martina and Buechler, Christa and Pavel, Vlad (2023) Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (24): 17518. ISSN 1661-6596, 1422-0067
Full text not available from this repository. (Request a copy)Abstract
T cell depletion and functional impairment are characteristics of sepsis. CD137 is a costimulatory receptor on activated T cells, while soluble CD137 (sCD137) inhibits CD137 signaling. This study found elevated sCD137 levels in the plasma of patients with systemic inflammatory response syndrome (SIRS), sepsis, or septic shock compared to healthy controls. The sCD137 levels negatively correlated with the C-reactive protein and positively with procalcitonin and interleukin-6. There was no difference in sCD137 levels based on ventilation, dialysis, or vasopressor treatment. Patients with SARS-CoV-2, Gram-positive, or Gram-negative bacterial infections had similar sCD137 levels as noninfected individuals. Notably, higher plasma sCD137 levels were observed in non-survivors compared to survivors in both the SIRS/sepsis group and the SARS-CoV-2 subgroup. In conclusion, plasma sCD137 levels are associated with severe illness and survival in critically ill patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SEPSIS; 4-1BB; EXPRESSION; PROTEIN; sCD137; COVID-19; sepsis; bacterial infection; survival |
| Subjects: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2024 12:59 |
| Last Modified: | 11 Mar 2024 12:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59642 |
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