Kurz, Bernadett and Schreiver, Ines and Siewert, Katherina and Haslboeck, Birgit and Weiss, Katharina T. and Hannemann, Julia and Berner, Bianca and von Eichborn, Maria Isabel and Berneburg, Mark and Baeumler, Wolfgang (2023) Investigation of Adverse Reactions in Tattooed Skin through Histological and Chemical Analysis. DERMATOLOGY, 239 (5). pp. 782-793. ISSN 1018-8665, 1421-9832
Full text not available from this repository. (Request a copy)Abstract
Background: Just as the number of tattooed people has increased in recent years, so has the number of adverse reactions in tattooed skin. Tattoo colourants contain numerous, partly unidentified substances, which have the potential to provoke adverse skin reactions like allergies or granulomatous reactions. Identification of the triggering substances is often difficult or even impossible. Methods: Ten patients with typical adverse reactions in tattooed skin were enrolled in the study. Skin punch biopsies were taken and the paraffin-embedded specimens were analysed by standard haematoxylin and eosin and anti-CD3 stainings. Tattoo colourants provided by patients and punch biopsies of patients were analysed with different chromatography and mass spectrometry methods and X-ray fluorescence. Blood samples of 2 patients were screened for angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R). Results: Histology showed variable skin reactions such as eosinophilic infiltrate, granulomatous reactions, or pseudolymphoma. CD3+ T lymphocytes dominated the dermal cellular infiltrate. Most patients had adverse skin reactions in red tattoos (n = 7), followed by white tattoos (n = 2). The red tattooed skin areas predominantly contained Pigment Red (P.R.) 170, but also P.R. 266, Pigment Orange (P.O.) 13, P.O. 16, and Pigment Blue (P.B.) 15. The white colourant of 1 patient contained rutile titanium dioxide but also other metals like nickel and chromium and methyl dehydroabietate - known as the main ingredient of colophonium. None of the 2 patients showed increased levels of ACE and sIL-2R related to sarcoidosis. Seven of the study participants showed partial or complete remission after treatment with topical steroids, intralesional steroids, or topical tacrolimus. Conclusions: The combination of the methods presented might be a rational approach to identify the substances that trigger adverse reactions in tattoos. Such an approach might help make tattoo colourants safer in the future if such trigger substances could be omitted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ALLERGIC CONTACT-DERMATITIS; DELAYED-HYPERSENSITIVITY; COMPLICATIONS; PIGMENTS; SARCOIDOSIS; RADIATION; LASER; INKS; Adverse tattoo reactions; Hypersensitivity; Azo pigment; Analytical chemistry; Histology |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Mar 2024 14:47 |
| Last Modified: | 11 Mar 2024 14:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59667 |
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