Broer, P. Niclas and Aung, Thiha and Heidekrueger, Paul I. and Prantl, L. and Narayan, Deepak (2017) Divisive influence of interleukin-1 receptor antagonist polymorphisms in melanoma patients. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 67 (3-4). pp. 319-326. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
OBJECTIVE: The interleukin-1 receptor antagonist (IL-1RA) contributes to tumor survival and progression in multiple cancer entities. IL-1RA polymorphisms influence IL-1RA expression patterns and function. A known polymorphism was correlated with clinical outcomes in melanoma patients with particularly aggressive disease. METHODS: DNA of 343 controls and 97 melanoma patients with poor prognostic indicators (time from diagnosis to death, nodal status, metastasis) was analyzed for a variable number of tandem repeat polymorphisms (VNTR) of the IL-1RA gene. Five alleles containing two (allele 2), three (allele 4), four (allele 1), five (allele 3) or six (allele 5) 86-bp repeats were targeted via PCR amplification. RESULTS: Genotype 1/2 is less common in the melanoma patient group vs. the control (28.8% vs. 39.6%; p = 0.06). Significant was the stage of the melanoma in order to predict the survivability (p = 0.008). The 1/1 and 1/2 genotype appeared to have lower hazards ratios than the 2/2 genotype (p > 0.05). CONCLUSIONS: Compared to the general population, the distribution of alleles coding for IL-1RA is different in melanoma patients. This alteration and the potential impact on tumor protein function and systemic inflammatory response may warrant further investigation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE POLYMORPHISM; PANCREATIC-CANCER; PLASMA-LEVELS; IL-1-BETA; RISK; IL-1; CARCINOGENESIS; ANGIOGENESIS; INFLAMMATION; EXPRESSION; Melanoma; interleukin-1 receptor antagonist; IL-1RA; polymorphism; inflammation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 26 Apr 2019 11:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/597 |
Actions (login required)
 |
View Item |
