Wester, Michael and Arzt, Michael and Sinha, Frederick and Maier, Lars Siegfried and Lebek, Simon (2023) Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing. BIOMEDICINES, 11 (11): 3038. ISSN 2227-9059
Full text not available from this repository. (Request a copy)Abstract
Heart failure with preserved ejection fraction (HFpEF) is emerging as a widespread disease with global socioeconomic impact. Patients with HFpEF show a dramatically increased morbidity and mortality, and, unfortunately, specific treatment options are limited. This is due to the various etiologies that promote HFpEF development. Indeed, cluster analyses with common HFpEF comorbidities revealed the existence of several HFpEF phenotypes. One especially frequent, yet underappreciated, comorbidity is sleep-disordered breathing (SDB), which is closely intertwined with the development and progression of the "obese HFpEF phenotype". The following review article aims to provide an overview of the common HFpEF etiologies and phenotypes, especially in the context of SDB. As general HFpEF therapies are often not successful, patient- and phenotype-individualized therapeutic strategies are warranted. Therefore, for the "obese HFpEF phenotype", a better understanding of the mechanistic parallels between both HFpEF and SDB is required, which may help to identify potential phenotype-individualized therapeutic strategies. Novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing further broaden the groundwork for deeper insights into pathomechanisms and precision medicine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROTEIN-KINASE-II; POSITIVE AIRWAY PRESSURE; INTERMITTENT HYPOXIA; CARDIAC-HYPERTROPHY; INSULIN-RESISTANCE; APNEA; DYSFUNCTION; INFLAMMATION; PREVALENCE; ACTIVATION; heart failure; HFpEF; obstructive sleep apnea; central sleep apnea; pathomechanisms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2024 10:37 |
| Last Modified: | 19 Mar 2024 10:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59715 |
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