Bywalez, Wolfgang G. and Patirniche, Dinu and Rupprecht, Vanessa and Stemmler, Martin and Herz, Andreas V. M. and Palfi, Denes and Rozsa, Balazs and Egger, Veronica (2015) Local Postsynaptic Voltage-Gated Sodium Channel Activation in Dendritic Spines of Olfactory Bulb Granule Cells. NEURON, 85 (3). pp. 590-601. ISSN 0896-6273, 1097-4199
Full text not available from this repository. (Request a copy)Abstract
Neuronal dendritic spines have been speculated to function as independent computational units, yet evidence for active electrical computation in spines is scarce. Here we show that strictly local voltage-gated sodium channel (Na-v) activation can occur during excitatory postsynaptic potentials in the spines of olfactory bulb granule cells, which we mimic and detect via combined two-photon uncaging of glutamate and calcium imaging in conjunction with whole-cell recordings. We find that local Na-v activation boosts calcium entry into spines through high-voltage-activated calcium channels and accelerates postsynaptic somatic depolarization, without affecting NMDA receptor-mediated signaling. Hence, Na-v-mediated boosting promotes rapid output from the reciprocal granule cell spine onto the lateral mitral cell dendrite and thus can speed up recurrent inhibition. This striking example of electrical compartmentalization both adds to the understanding of olfactory network processing and broadens the general view of spine function.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DENDRODENDRITIC INHIBITION; SYNAPTIC AMPLIFICATION; NMDA RECEPTORS; GABA RELEASE; K+ CHANNELS; RAT-BRAIN; NECK; INTERNEURONS; MEMBRANE; SIGNALS; |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Neurophysiologie (Prof. Dr. Veronica Egger) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Jul 2019 11:48 |
| Last Modified: | 24 Jul 2019 11:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5973 |
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