Chronic Active Epstein-Barr Virus Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-specific T Cells

Meedt, Elisabeth and Weber, Daniela and Bonifacius, Agnes and Eiz-Vesper, Britta and Maecker-Kolhoff, Britta and Delecluse, Susanne and Delecluse, Henri-Jacques and Lorenz, Myriam and Schwarz, Klaus and Meedt, Stefan T. and Braess, Jan and Herr, Wolfgang and Holler, Ernst and Edinger, Matthias and Wolff, Daniel (2023) Chronic Active Epstein-Barr Virus Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-specific T Cells. CLINICAL INFECTIOUS DISEASES, 76 (12). pp. 2200-2202. ISSN 1058-4838, 1537-6591

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Abstract

We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.

Item Type: Article
Uncontrolled Keywords: ; CAEBV; EBV-specific T cells; allogeneic stem cell transplantation; anti-T-lymphocyte globulin
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Depositing User: Dr. Gernot Deinzer
Date Deposited: 12 Mar 2024 12:19
Last Modified: 12 Mar 2024 12:19
URI: https://pred.uni-regensburg.de/id/eprint/59751

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