Kehrer, Andreas and Hollmann, Katharina S. and Klein, Silvan M. and Anker, Alexandra M. and Tamm, Ernst R. and Prantl, Lukas and Engelmann, Simon and Knoedler, Samuel and Knoedler, Leonard and Ruewe, Marc (2023) Histomorphometry of the Sural Nerve for Use as a CFNG in Facial Reanimation Procedures. JOURNAL OF CLINICAL MEDICINE, 12 (14): 4627. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Facial palsy (FP) is a debilitating nerve pathology. Cross Face Nerve Grafting (CFNG) describes a surgical technique that uses nerve grafts to reanimate the paralyzed face. The sural nerve has been shown to be a reliable nerve graft with little donor side morbidity. Therefore, we aimed to investigate the microanatomy of the sural nerve. Biopsies were obtained from 15 FP patients who underwent CFNG using sural nerve grafts. Histological cross-sections were fixated, stained with PPD, and digitized. Histomorphometry and a validated software-based axon quantification were conducted. The median age of the operated patients was 37 years (5-62 years). There was a significant difference in axonal capacity decrease towards the periphery when comparing proximal vs. distal biopsies (p = 0.047), while the side of nerve harvest showed no significant differences in nerve caliber (proximal p = 0.253, distal p = 0.506) and axonal capacity for proximal and distal biopsies (proximal p = 0.414, distal p = 0.922). Age did not correlate with axonal capacity (proximal: R = -0.201, p = 0.603; distal: R = 0.317, p = 0.292). These novel insights into the microanatomy of the sural nerve may help refine CFNG techniques and individualize FP patient treatment plans, ultimately improving overall patient outcomes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CROSS-FACE NERVE; ASSESSMENT SCALE; GROWTH-FACTOR; MOTOR-NERVE; AXON REGENERATION; ULNAR NERVE; GRAFT; MUSCLE; ANATOMY; TRANSFERS; axons; analysis; dissection; facial injuries; surgery; facial muscles; innervation; facial nerve; anatomy and histology; humans; nerve fibers; facial paralysis; reconstructive surgical procedures |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2024 12:35 |
| Last Modified: | 12 Mar 2024 12:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59761 |
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