Geismann, Florian and Handschuh, Stefan and Malfertheiner, Maximilian and Salzberger, Bernd and Bauernfeind, Stilla and Hitzenbichler, Florian and Simon, Michaela and Caplunik-Pratsch, Aila and Schneider-Brachert, Wulf and Wiest, Clemens and Ruegamer, Tamara and Mohr, Arno (2023) Short report: impact of selective reporting of antibiotic susceptibility testing on antibiotic use in patients with bloodstream infection with Enterococcus faecalis. INFECTION, 51 (5). pp. 1557-1562. ISSN 0300-8126, 1439-0973
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IntroductionBloodstream infections with Enterococcus faecalis are associated with relevant morbidity and mortality. Targeted antimicrobial therapy is essential. The choice of an adequate treatment may be challenging when susceptibility testing offers different options. Selective reporting of antibiotic susceptibility test results might lead to a more tailored antibiotic therapy and could therefore be an important antimicrobial stewardship program intervention. The aim of this study was to analyse whether the introduction of selective reporting of antibiotic test results leads to a more targeted antibiotic therapy in patients with bloodstream infection with Enterococcus faecalis.MethodsThis study was performed as a retrospective cohort study at the University Hospital Regensburg, Germany. All patients with blood cultures positive for Enterococcus faecalis between March 2003 and March 2022 were analysed. In February 2014 selective reporting of antibiotic susceptibility test results omitting sensitivity results for agents not recommended was introduced.Results263 patients with blood cultures positive for Enterococcus faecalis were included. After introduction of selective reporting of antibiotic tests (AI) significantly more patients received ampicillin than before introduction of selective reporting (BI) (9.6% BI vs. 34.6% AI, p < 0.001).ConclusionSelective reporting of antibiotic susceptibility test results led to a significantly higher use of ampicillin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | URINARY-TRACT-INFECTIONS; STAPHYLOCOCCUS-AUREUS; APPROPRIATENESS; ENDOCARDITIS; Enterococcus faecalis; Bloodstream infection; Infectious endocarditis; Antimicrobial stewardship |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2024 12:40 |
| Last Modified: | 12 Mar 2024 12:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59769 |
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