Gryksa, Katharina and Schmidtner, Anna K. and Masis-Calvo, Marianella and Rodriguez-Villagra, Odir A. and Havasi, Andrea and Wirobski, Gwendolyn and Maloumby, Rodrigue and Jaegle, Herbert and Bosch, Oliver J. and Slattery, David A. and Neumann, Inga D. (2023) Selective breeding of rats for high (HAB) and low (LAB) anxiety-related behaviour: A unique model for comorbid depression and social dysfunctions. PERGAMON-ELSEVIER SCIENCE LTD, OXFORD.
Full text not available from this repository. (Request a copy)Abstract
Animal models of selective breeding for extremes in emotionality are a strong experimental approach to model psychopathologies. They became indispensable in order to increase our understanding of neurobiological, genetic, epigenetic, hormonal, and environmental mechanisms contributing to anxiety disorders and their association with depressive symptoms or social deficits. In the present review, we extensively discuss Wistar rats selectively bred for high (HAB) and low (LAB) anxiety-related behaviour on the elevated plus-maze. After 30 years of breeding, we can confirm the prominent differences between HAB and LAB rats in trait anxiety, which are accompanied by consistent differences in depressive-like, social and cognitive behaviours. We can further confirm a single nucleotide polymorphism in the vasopressin promotor of HAB rats causative for neuropeptide overexpression, and show that low (or high) anxiety and fear levels are unlikely due to visual dysfunctions. Thus, HAB and LAB rats continue to exist as a reliable tool to study the multiple facets underlying the pathology of high trait anxiety and its comorbidity with depression-like behaviour and social dysfunctions.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; NEUROENDOCRINE STRESS RESPONSES; COMBINED DEXAMETHASONE/CRH TEST; CORONARY-HEART-DISEASE; MENTAL-HEALTH SURVEY; ANIMAL-MODEL; NEUROPEPTIDE-S; INDIVIDUAL-DIFFERENCES; PRENATAL STRESS; Animal model; Depression; Social behaviour; Stress; Vasopressin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Jan 2024 12:57 |
| Last Modified: | 31 Jan 2024 12:57 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59800 |
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