Reis, Caio Luiz Bitencourt and Maranon-Vasquez, Guido Artemio and Matsumoto, Mirian Aiko Nakane and Baratto-Filho, Flares and Stuani, Maria Bernadete Sasso and Proff, Peter and Kirschneck, Christian and Kuechler, Erika Calvano (2023) Single nucleotide polymorphisms in odontogenesis-related genes associated with tooth-size discrepancy. AUSTRALASIAN ORTHODONTIC JOURNAL, 39 (1). pp. 86-95. ISSN 2207-7472, 2207-7480
Full text not available from this repository. (Request a copy)Abstract
Introduction: The present study aimed to determine the association between single nucleotide polymorphisms (SNPs) in RUNX2, SMAD6, BMP2, and BMP4 genes in relation to tooth-size discrepancy (TSD).Methods: A cross-sectional study of patients undergoing orthodontic treatment measured the mesiodistal width of permanent teeth from pretreatment dental casts. Sixty-two patients were included in the study and TSD was assessed according to the Bolton analysis. The patients were allocated into a control group (without a TSD), an anterior excess group and an overall excess group. Genomic DNA was extracted from saliva samples, and SNPs previously associated with tooth size were evaluated using a real-time polymerase chain reaction (PCR) system. The Fisher exact test was performed to compare genotype and allele frequencies at an alpha = 0.05. An Odds Ratio (OR) and 95% Confidence Interval (95% CI) were calculated.Results: The rs59983488 SNP in the RUNX2 gene was significantly related to the presence of anterior mandibular tooth-size excess in allele (T allele: p < 0.001; OR = 11.74; 95% CI =2.61-55.80), and genotype models (GT genotype: p = 0.002; OR = 12.69; 95% CI = 2.47-64.83). The rs3934908 SNP in the SMAD6 gene was significantly associated with the presence of an overall maxillary tooth-size excess in allele (T allele: p < 0.001) and genotype models (TT genotype: p = 0.010).Conclusion: The present results suggest that SNPs in RUNX2 (rs59983488) and SMAD6 (rs3934908) genes may be associated with the presence of tooth-size excess.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MALOCCLUSION; RUNX2; PCR; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Mar 2024 14:20 |
| Last Modified: | 12 Mar 2024 14:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59806 |
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