Haimerl, M. and Bruenn, K. and Poelsterl, S. and Beyer, L. P. and Wiesinger, I. and Stroszczynski, C. and Jung, E. -M. and Wiggermann, P. (2017) Quantitative evaluation of real-time maximum liver capacity (LiMAx) and time intensity curve (TIC) analysis in CEUS-based microperfusion. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION, 67 (3-4). pp. 373-382. ISSN 1386-0291, 1875-8622
Full text not available from this repository. (Request a copy)Abstract
PURPOSE: To compare the diagnostic performance of real-time maximum liver capacity (LiMAx) with dynamic contrast-enhanced ultrasound (CEUS)-based liver microcirculation. MATERIALS AND METHODS: 23 patients underwent liver function capacity (LiMAx) test and consecutive or previous CEUS examinations. A bolus injection of 1.4 ml sulfur hexafluoride microbubbles was administered for CEUS measurements (1-6 MHz) and quantitative perfusion analysis (TIC) was performed with an integrated perfusion software using stored cine-loops. Two perfusion-parameters, time to peak (TtoP) and area under the curve (Area), were evaluated in liver parenchyma and portal vein using TIC analysis. To compare quantification parameters, patients were classified in patients representing a healthy population (LiMAx value >315 mu g/kg/h) and those representing patients with liver disease (LiMAx value <315 mu g/kg/h). RESULTS: Comparing perfusion parameters derived from portal vein measurements, TtoP and Area were higher in patients with normal liver function TtoP: 25.0 +/- 8.4 s, Area: 1483 +/- 920 a.u. compared to patients with impaired liver function TtoP: 22.4 +/- 14.0 s; Area 1351 +/- 1212 a. u. This difference however was not statistically significant (p = 0.52, p = 0.48). In parameters derived from measurements in liver parenchyma TtoPwas higher (38.5 +/- 11.3 s) and Areawas lower (999 +/- 632 a. u.) in patients with normal liver function compared to patients with impaired liver function (TtoP; 30.6 +/- 11.0 s, p = 0.156; Area: 1202 +/- 719 a. u.) (p = 0.16, p = 0.56). In a simple linear regression model, none of the perfusion parameters measured in portal vein (TtoP portal, Area portal) and liver parenchyma (TtoP liver, Area liver) correlated significantly with respective LiMAx values (p = 0.194-0.950). CONCLUSION: Within the framework of this study, CEUS-based perfusion parameters were not able to assess severity of liver disease, assessed with LiMAx-test.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST-ENHANCED ULTRASOUND; CHRONIC HEPATITIS-C; NONINVASIVE DIAGNOSIS; COMPENSATED CIRRHOSIS; PORTAL-HYPERTENSION; FIBROSIS; DISEASE; ULTRASONOGRAPHY; SEVERITY; TRANSPLANTATION; Liver capacity; LiMAx; CEUS; microcirculation; liver function |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 26 Apr 2019 11:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/599 |
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