Tews, Hauke C. and Elger, Tanja and Grewal, Thomas and Weidlich, Simon and Vitali, Francesco and Buechler, Christa (2023) Fecal and Urinary Adipokines as Disease Biomarkers. MDPI, BASEL.
Full text not available from this repository. (Request a copy)Abstract
The use of biomarkers is of great clinical value for the diagnosis and prognosis of disease and the assessment of treatment efficacy. In this context, adipokines secreted from adipose tissue are of interest, as their elevated circulating levels are associated with a range of metabolic dysfunctions, inflammation, renal and hepatic diseases and cancers. In addition to serum, adipokines can also be detected in the urine and feces, and current experimental evidence on the analysis of fecal and urinary adipokine levels points to their potential as disease biomarkers. This includes increased urinary adiponectin, lipocalin-2, leptin and interleukin-6 (IL-6) levels in renal diseases and an association of elevated urinary chemerin as well as urinary and fecal lipocalin-2 levels with active inflammatory bowel diseases. Urinary IL-6 levels are also upregulated in rheumatoid arthritis and may become an early marker for kidney transplant rejection, while fecal IL-6 levels are increased in decompensated liver cirrhosis and acute gastroenteritis. In addition, galectin-3 levels in urine and stool may emerge as a biomarker for several cancers. With the analysis of urine and feces from patients being cost-efficient and non-invasive, the identification and utilization of adipokine levels as urinary and fecal biomarkers could become a great advantage for disease diagnosis and predicting treatment outcomes. This review article highlights data on the abundance of selected adipokines in urine and feces, underscoring their potential to serve as diagnostic and prognostic biomarkers.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | GELATINASE-ASSOCIATED LIPOCALIN; INFLAMMATORY-BOWEL-DISEASE; SERUM ADIPONECTIN LEVELS; RENAL DYSFUNCTION; ADIPOSE-TISSUE; INSULIN-RESISTANCE; LEPTIN MEASUREMENT; EGYPTIAN PATIENTS; PLASMATIC LEVELS; GENE-EXPRESSION; adiponectin; lipocalin-2; leptin; galectin-3; chemerin; interleukin-6; kidney; liver; inflammatory bowel disease; biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2024 08:59 |
| Last Modified: | 23 Apr 2024 08:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59906 |
Actions (login required)
 |
View Item |
