du Halgouet, Anastasia and Darbois, Aurelie and Alkobtawi, Mansour and Mestdagh, Martin and Alphonse, Aurelia and Premel, Virginie and Yvorra, Thomas and Colombeau, Ludovic and Rodriguez, Raphael and Zaiss, Dietmar and El Morr, Yara and Bugaut, Helene and Legoux, Francois and Perrin, Laetitia and Aractingi, Selim and Golub, Rachel and Lantz, Olivier and Salou, Marion (2023) Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing. IMMUNITY, 56 (1). 78-+. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Tissue repair processes maintain proper organ function following mechanical or infection-related damage. In addition to antibacterial properties, mucosal associated invariant T (MAIT) cells express a tissue repair transcriptomic program and promote skin wound healing when expanded. Herein, we use a human-like mouse model of full-thickness skin excision to assess the underlying mechanisms of MAIT cell tissue repair function. Single-cell RNA sequencing analysis suggested that skin MAIT cells already express a repair program at steady state. Following skin excision, MAIT cells promoted keratinocyte proliferation, thereby accelerating healing. Using skin grafts, parabiosis, and adoptive transfer experiments, we show that MAIT cells migrated into the wound in a T cell receptor (TCR)-independent but CXCR6 chemokine receptor-dependent manner. Amphiregulin secreted by MAIT cells following excision promoted wound healing. Expression of the repair function was probably independent of sustained TCR stimulation. Overall, our study provides mechanistic insights into MAIT cell wound healing function in the skin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DELTA T-CELLS; IN-VIVO; TISSUE-REPAIR; TGF-BETA; PLZF; MR1; TCR; SURVEILLANCE; ACTIVATION; EXPRESSION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Pathologie Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Jan 2024 10:44 |
| Last Modified: | 30 Jan 2024 10:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/59961 |
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