Kirschneck, Christian and Fanghaenel, Jochen and Wahlmann, Ulrich and Wolf, Michael and Roldan, J. Camilo and Proff, Peter (2017) Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model. ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 210. pp. 32-43. ISSN 0940-9602, 1618-0402
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Background: Many adult orthodontic patients suffer from chronic periodontitis with recurrent episodes of active periodontal inflammation. As their number is steadily increasing, orthodontists are more and more frequently challenged by respective treatment considerations. However, little is currently known regarding interactive effects on undesired dental root resorption (DRR), tooth movement velocity, periodontal bone loss and the underlying cellular and tissue reactions. Material and methods: A total of 63 male Fischer344 rats were used in three consecutive experiments employing 21 animals each (A/B/C), randomly assigned to 3 experimental groups (n = 7, 1/2/3), respectively: (A) CBCT; (B) histology/serology; (C) RT-qPCR (1) control: (2) orthodontic tooth movement (OTM) of the first/second upper left molars (NiTi coil spring, 0.25 N); (3) OTM with experimentally induced periodontitis (cervical silk ligature). After 14 days of OTM, we quantified blood leukocyte level, DRR, osteoclast activity and relative gene expression of inflammatory and osteoclast marker genes within the dental-periodontal tissue as well as tooth movement velocity and periodontal bone loss after 14 and 28 days. Results: The experimentally induced periodontal bone loss was significantly increased by concurrent orthodontic force application. Periodontal inflammation during OTM on the other hand significantly augmented the extent of DRR, relative expression of inflammatory/osteoclast marker genes, blood leukocyte level and periodontal osteoclast activity. In addition, contrary to previous studies, we observed a significant increase in tooth movement velocity. Conclusions: Although accelerated tooth movement would be favourable for orthodontic treatment, our results suggest that orthodontic interventions should only be performed after successful systematic periodontal therapy and paused in case of recurrent active inflammation. (C) 2016 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OXYTALAN FIBER SYSTEM; LIGAMENT CELLS; IN-VIVO; EXPRESSION; CYTOKINE; FORCES; TISSUE; INTERRELATIONSHIP; ADOLESCENTS; ANIMALS; Periodontal ligament; Periodontitis; Root resorption; Tooth movement; Alveolar bone loss |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:57 |
| Last Modified: | 13 Feb 2019 14:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60 |
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