Bitencourt Reis, Caio Luiz and Matsumoto, Mirian Aiko Nakane and Baratto-Filho, Flares and Scariot, Rafaela and Stuani, Maria Bernadete Sasso and Lourenco Romano, Fabio and Della Coletta, Ricardo and de Oliveira, Daniela Silva Barroso and Proff, Peter and Kirschneck, Christian and Kuechler, Erika Calvano (2023) Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study. HEAD & FACE MEDICINE, 19 (1): 26. ISSN , 1746-160X
Full text not available from this repository. (Request a copy)Abstract
BackgroundThis study evaluated if genetic variations in the WNT family members and RUNX2 are associated with craniofacial maturation, investigating dental and skeletal maturity in children and teenagers.MethodsRadiographs from pre-orthodontic treatment of Brazilian patients (7 to 17 years-old) were used to assess dental (panoramic radiographs) and skeletal maturity (cephalometric radiographs). The chronological age (CA) was calculated based on the date of birth and the time the radiographs were performed. For the dental maturity analysis, the Demirjian (1973) method was used and a delta [dental age - chronological age (DA-CA)] was calculated. For the skeletal maturity analysis, the Baccetti et al. (2005) method was used and the patients were classified as "delayed skeletal maturation", "advanced skeletal maturation" or "normal skeletal maturation". DNA isolated from buccal cells was used for genotyping of two genetic variations in WNT family genes: rs708111 (G > A) in WNT3A and rs1533767 (G > A) in WNT11; and two genetic variations in RUNX2: rs1200425 (G > A) and rs59983488 (G > T). A statistical analysis was performed and values of p < 0.05 indicated a significant difference.ResultsThere were no associations between dental maturity and genotypes (p > 0.05). In the skeletal maturity analysis, the allele A in the rs708111 (WNT3A) was statistically more frequent in patients with delayed skeletal maturation (Prevalence Ratio = 1.6; 95% Confidence Interval = 1.00 to 2.54; p-value = 0.042).ConclusionsThe rs708111 in the WNT3A gene impacts on skeletal maturation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDHOOD OBESITY; AGE ESTIMATION; DIFFERENTIATION; CELLS; DEMIRJIAN; MATURITY; ERUPTION; GROWTH; Craniofacial growthm dental development; Skeletal maturation; Genetic variation; WNT; RUNX2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Kieferorthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Mar 2024 15:44 |
| Last Modified: | 13 Mar 2024 15:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60035 |
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