Kauke-Navarro, Martin and Knoedler, Samuel and Panayi, Adriana C. and Knoedler, Leonard and Noel, Olivier F. and Pomahac, Bohdan (2023) Regulatory T Cells: Liquid and Living Precision Medicine for the Future of VCA. TRANSPLANTATION, 107 (1). pp. 86-97. ISSN 0041-1337, 1534-6080
Full text not available from this repository. (Request a copy)Abstract
Transplant rejection remains a challenge especially in the field of vascularized composite allotransplantation (VCA). To blunt the allo-reactive immune response, stable levels of maintenance immunosupression are required. However, the need for lifelong immunosuppression poses the risk of severe side effects, such as increased risk of infection, metabolic complications, and malignancies. To balance therapeutic efficacy and medication side effects, immunotolerance promoting immune cells (especially regulatory T cells [Treg]) have become of great scientific interest. This approach leverages immune system mechanisms that usually ensure immunotolerance toward self-antigens and prevent autoimmunopathies. Treg can be bioengineered to express a chimeric antigen receptor or a T-cell receptor. Such bioengineered Treg can target specific antigens and thereby reduce unwanted off-target effects. Treg have demonstrated beneficial clinical effects in solid organ transplantation and promising in vivo data in VCAs. In this review, we summarize the functional, phenotypic, and immunometabolic characteristics of Treg and outline recent advancements and current developments regarding Treg in the field of VCA and solid organ transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASCULARIZED COMPOSITE ALLOTRANSPLANTATION; ANTIBODY-MEDIATED REJECTION; IN-VIVO; ALLOGRAFT-REJECTION; INFECTIOUS TOLERANCE; SKIN REJECTION; TRANSPLANTATION; THERAPY; HAND; FACE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Zentren des Universitätsklinikums Regensburg > Regensburger Centrum für Interventionelle Immunologie (RCI) Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Plastische-, Hand- und Wiederherstellungschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 May 2024 09:35 |
| Last Modified: | 14 May 2024 09:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60045 |
Actions (login required)
 |
View Item |
