Riedl, Moritz and Bretschneider, Henriette and Dienst, Michael and Guenther, Klaus-Peter and Landgraeber, Stefan and Schroeder, Jorg and Trattnig, Siegfried and Fickert, Stefan (2023) Two-Year Results of Injectable Matrix-Associated Autologous Chondrocyte Transplantation in the Hip Joint: Significant Improvement in Clinical and Radiological Assessment. JOURNAL OF CLINICAL MEDICINE, 12 (17): 5468. ISSN , 2077-0383
Full text not available from this repository. (Request a copy)Abstract
Purpose: Articular cartilage defects are a prevalent consequence of femoroacetabular impingement (FAI) in young active patients. In accordance with current guidelines, large chondral lesions of the hip joint over 2 cm(2) are recommended to be treated with matrix-associated, autologous chondrocyte transplantation (MACT); however, the conditions in the hip joint are challenging for membrane-based MACT options. Injectable MACT products can solve this problem. The purpose of the trial was to assess clinical and radiological outcomes 24 months after injectable MACT of focal chondral lesions caused by FAI. Methods: We present data of 21 patients with focal cartilage defects of the hip [3.0 +/- 1.4 cm(2) (mean +/- SD)], ICRS Grade III and IV caused by CAM-type impingement, who underwent arthroscopic MACT (NOVOCART((R)) Inject) and FAI correction. The outcome was evaluated with the patient-reported outcome instruments iHOT33 and EQ-5D-5L (index value and VAS), whilst graft morphology was assessed based on the MOCART score over a follow-up period of 24 months. Results: The iHOT33 score increased significantly from 52.9 +/- 21.1 (mean +/- SD) preoperatively to 85.8 +/- 14.8 (mean +/- SD; p < 0.0001) 24 months postoperatively. The EQ-5D-5L index value (p = 0.0004) and EQ-5D VAS (p = 0.0006) showed a statistically significant improvement as well. MRI evaluation after 24 months showed successful integration of the implant in all patients with a complete defect filling in 11 of 14 patients. Conclusions: Injectable MACT for the treatment of full-thickness chondral lesions of the hip joint due to FAI in combination with FAI correction improved symptoms, function, and quality of life in the treated cohort. Alongside the treatment of the underlying pathology by the FAI correction, the developed cartilage defect can be successfully repaired by MACT, which is of considerable clinical relevance.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARTILAGE REPAIR TISSUE; ARTICULAR-CARTILAGE; CHONDRAL DEFECTS; HIGH-RESOLUTION; FEMOROACETABULAR IMPINGEMENT; ARTHROSCOPIC TREATMENT; OSTEOARTHRITIS; IMPLANTATION; HYDROGEL; hip-preserving surgery; hip arthroscopy; matrix-associated autologous chondrocyte transplantation; MACT; cartilage defect; femoroacetabular impingement |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Mar 2024 16:03 |
| Last Modified: | 13 Mar 2024 16:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60051 |
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