Diaz, Fernando Castillo and Mottarlini, Francesca and Targa, Giorgia and Rizzi, Beatrice and Fumagalli, Fabio and Caffino, Lucia (2023) Recency memory is altered in cocaine-withdrawn adolescent rats: Implication of cortical mTOR signaling. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 127: 110822. ISSN 0278-5846, 1878-4216
Full text not available from this repository. (Request a copy)Abstract
In humans, cocaine abuse during adolescence poses a significant risk for developing cognitive deficits later in life. Among the regions responsible for cognitive processes, the medial prefrontal cortex (mPFC) modulates temporal order information via mechanisms involving the mammalian-target of rapamycin (mTOR)-mediated pathway and protein synthesis regulation. Accordingly, our goal was to study the effect of repeated cocaine exposure during both adolescence and adulthood on temporal memory by studying the mTOR pathway in the mPFC. Adolescent or adult rats underwent repeated cocaine injections for 15 days and, after two weeks of withdrawal, engaged in the temporal order object recognition (TOOR) test.We found that repeated cocaine exposure during adolescence impaired TOOR performance, while control or adult-treated animals showed no impairments. Moreover, activation of the mTOR-S6-eEF2 pathway following the TOOR test was diminished only in the adolescent cocaine-treated group. Notably, inhibition of the mTORmediated pathway by rapamycin injection impaired TOOR performance in naive adolescent and adult animals, revealing this pathway to be a critical component in regulating recency memory. Our data indicate that withdrawal from cocaine exposure impairs recency memory via the dysregulation of protein translation mechanisms, but only when cocaine is administered during adolescence.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEDIAL PREFRONTAL CORTEX; NUCLEUS-ACCUMBENS; DEVELOPMENTAL EXPOSURE; DRUG SEEKING; EXPRESSION; RECOGNITION; MECHANISM; RECEPTOR; PATHWAY; KINASE; Adolescence; Cocaine; Prefrontal cortex; mTOR; Rapamycin; Temporal order memory |
| Subjects: | 500 Science > 550 Earth sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Jan 2024 12:48 |
| Last Modified: | 31 Jan 2024 12:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60114 |
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