Tews, Hauke Christian and Schmelter, Franziska and Kandulski, Arne and Buechler, Christa and Schmid, Stephan and Schlosser, Sophie and Elger, Tanja and Loibl, Johanna and Sommersberger, Stefanie and Fererberger, Tanja and Gunawan, Stefan and Kunst, Claudia and Guelow, Karsten and Bettenworth, Dominik and Foeh, Bandik and Maass, Carlos and Solbach, Philipp and Guenther, Ulrich L. and Derer, Stefanie and Marquardt, Jens U. and Sina, Christian and Mueller, Martina (2023) Unique Metabolomic and Lipidomic Profile in Serum From Patients With Crohn's Disease and Ulcerative Colitis Compared With Healthy Control Individuals. OXFORD UNIV PRESS INC, CARY.
Full text not available from this repository. (Request a copy)Abstract
Background Accurate biomarkers for disease activity and progression in patients with inflammatory bowel disease (IBD) are a prerequisite for individual disease characterization and personalized therapy. We show that metabolic profiling of serum from IBD patients is a promising approach to establish biomarkers. The aim of this work was to characterize metabolomic and lipidomic serum profiles of IBD patients in order to identify metabolic fingerprints unique to the disease.Methods Serum samples were obtained from 55 patients with Crohn's disease (CD), 34 patients with ulcerative colitis (UC), and 40 healthy control (HC) individuals and analyzed using proton nuclear magnetic resonance spectroscopy. Classification of patients and HC individuals was achieved by orthogonal partial least squares discriminant analysis and univariate analysis approaches. Disease activity was assessed using the Gastrointestinal Symptom Rating Scale.Results Serum metabolome significantly differed between CD patients, UC patients, and HC individuals. The metabolomic differences of UC and CD patients compared with HC individuals were more pronounced than the differences between UC and CD patients. Differences in serum levels of pyruvic acid, histidine, and the branched-chain amino acids leucine and valine were detected. The size of low-density lipoprotein particles shifted from large to small dense particles in patients with CD. Of note, apolipoprotein A1 and A2 serum levels were decreased in CD and UC patients with higher fecal calprotectin levels. The Gastrointestinal Symptom Rating Scale is negatively associated with the concentration of apolipoprotein A2.Conclusions Metabolomic assessment of serum samples facilitated the differentiation of IBD patients and HC individuals. These differences were constituted by changes in amino acid and lipoprotein levels. Furthermore, disease activity in IBD patients was associated with decreased levels of the atheroprotective apolipoproteins A1 and A2. The metabolic and lipidomic serum profile of patients with inflammatory bowel disease was analyzed using proton nuclear magnetic resonance spectroscopy. A significantly altered profile in comparison with healthy control individuals was identified, characterized by more atherogenic properties.
| Item Type: | Other |
|---|---|
| Uncontrolled Keywords: | INFLAMMATORY-BOWEL-DISEASE; PROTON NMR-SPECTROSCOPY; LOW-DENSITY-LIPOPROTEIN; FECAL CALPROTECTIN; CHOLESTEROL; PLASMA; RISK; DYSLIPIDEMIA; ASSOCIATION; MICROBIOME; lipoprotein; apolipoprotein; metabolomics; IBD; amino acids; nuclear magnetic resonance spectroscopy; biomarker |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Apr 2024 12:30 |
| Last Modified: | 23 Apr 2024 12:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60121 |
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