Henze, Gina-Isabelle and Konzok, Julian and Kudielka, Brigitte M. and Wuest, Stefan and Nichols, Thomas E. and Kreuzpointner, Ludwig (2023) Associations between cortisol stress responses and limbic volume and thickness in young adults: An exploratory study. EUROPEAN JOURNAL OF NEUROSCIENCE, 58 (9). pp. 3962-3980. ISSN 0953-816X, 1460-9568
Full text not available from this repository. (Request a copy)Abstract
The investigation of the relationship between neural measures of limbic structures and hypothalamic pituitary adrenal axis responses to acute stress exposure in healthy young adults has so far focused in particular on task-based and resting state functional connectivity studies. Thus, the present study examined the association between limbic volume and thickness measures and acute cortisol responses to the psychosocial stress paradigm ScanSTRESS. Using Permutation Analysis of Linear Models controlling for sex, age and total brain volume, the associations between (sex-specific) cortisol increases and human connectome project style anatomical variables of limbic structures (i.e. volume and thickness) were investigated in 66 healthy and young (18-33 years) subjects (35 men, 31 women taking oral contraceptives). In addition, exploratory (sex-specific) bivariate correlations between cortisol increases and structural measures were conducted. The present data provide interesting new insights into the involvement of striato-limbic structures in psychosocial stress processing, suggesting that acute cortisol stress responses are also associated with mere structural measures of the human brain. Thus, our preliminary findings suggest that not only situation- and context-dependent reactions of the limbic system (i.e. blood oxygenation level-dependent reactions) are related to acute (sex-specific) cortisol stress responses but also basal and somewhat more constant structural measures. Our study hereby paves the way for further analyses in this context and highlights the relevance of the topic.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HPA AXIS RESPONSES; FUNCTIONAL CONNECTIVITY; HIPPOCAMPAL VOLUME; PSYCHOSOCIAL STRESS; SALIVARY CORTISOL; PREFRONTAL CORTEX; SEX-DIFFERENCES; AMYGDALA; BRAIN; ACTIVATION; amygdala; Human Connectome Project, HCP; ncl. caudatus; psychosocial stress; ScanSTRESS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie VII (Medizinische Psychologie, Psychologische Diagnostik und Methodenlehre) - Prof. Dr. Brigitte Kudielka |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2024 14:41 |
| Last Modified: | 14 Mar 2024 14:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60131 |
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