Alayash, Zoheir and Baumeister, Sebastian-Edgar and Holtfreter, Birte and Kocher, Thomas and Baurecht, Hansjoerg and Ehmke, Benjamin and Reckelkamm, Stefan Lars and Nolde, Michael (2023) Inhibition of tumor necrosis factor receptor 1 and the risk of periodontitis. FRONTIERS IN IMMUNOLOGY, 14: 1094175. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
AimTo investigate the effect of genetically proxied inhibition of tumor necrosis factor receptor 1 (TNFR1) on the risk of periodontitis. Materials and methodsGenetic instruments were selected from the vicinity of TNFR superfamily member 1A (TNFRSF1A) gene (chromosome 12; base pairs 6,437,923-6,451,280 as per GRCh37 assembly) based on their association with C-reactive protein (N= 575,531). Summary statistics of these variants were obtained from a genome-wide association study (GWAS) of 17,353 periodontitis cases and 28,210 controls to estimate the effect of TNFR1 inhibition on periodontitis using a fixed-effects inverse method. ResultsConsidering rs1800693 as an instrument, we found no effect of TNFR1 inhibition on periodontitis risk (Odds ratio (OR) scaled per standard deviation increment in CRP: 1.57, 95% confidence interval (CI): 0.38;6.46). Similar results were derived from a secondary analysis that used three variants (rs767455, rs4149570, and rs4149577) to index TNFR1 inhibition. ConclusionsWe found no evidence of a potential efficacy of TNFR1 inhibition on periodontitis risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GINGIVAL CREVICULAR FLUID; MENDELIAN RANDOMIZATION; FACTOR-ALPHA; RHEUMATOID-ARTHRITIS; THERAPY; DISEASE; tumor necrosis factor (TNF); periodonditis; cis-Mendelian randomization analysis; genetics; proinflammatory cytokine |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Mar 2024 14:58 |
| Last Modified: | 14 Mar 2024 14:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60136 |
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