Dzaman, Karolina and Czerwaty, Katarzyna and Reichert, Torsten E. and Szczepanski, Miroslaw J. and Ludwig, Nils (2023) Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (15): 12277. ISSN 1661-6596, 1422-0067
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Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MIDDLE-EAR CHOLESTEATOMA; EPITHELIAL-MESENCHYMAL TRANSITION; CELL-PROLIFERATION; SIGNALING PATHWAY; POSTTRANSCRIPTIONAL REGULATION; OSTEOCLAST DIFFERENTIATION; THERAPEUTIC TARGET; MIR-125 FAMILY; CIRCULAR RNA; KAPPA-B; cholesteatoma; microRNA; exosomes; small extracellular vesicles |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 May 2024 10:17 |
| Last Modified: | 08 May 2024 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60187 |
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