Baumeister, Sebastian-Edgar and Holtfreter, Birte and Reckelkamm, Stefan Lars and Hagenfeld, Daniel and Kocher, Thomas and Alayash, Zoheir and Ehmke, Benjamin and Baurecht, Hansjorg and Nolde, Michael (2023) Effect of interleukin-17 on periodontitis development: An instrumental variable analysis. JOURNAL OF PERIODONTOLOGY, 94 (5). pp. 616-621. ISSN 0022-3492, 1943-3670
Full text not available from this repository. (Request a copy)Abstract
BackgroundCirculating levels of interleukin-17 (IL-17) are associated with the presence and severity of periodontitis. However, whether IL-17 is causal for disease development is unknown. We investigated the effect of genetically proxied IL-17 on periodontitis using instrumental variable analysis. MethodsWe identified 12 genetic variants from genome-wide association study (GWAS) of 7760 European descent individuals, used these variants as instrumental variables for IL-17, and linked them to a GWAS of 17,353 clinical periodontitis cases and 28,210 European controls. Generalized weighted least squares analysis accounted for linkage disequilibrium of variants. ResultsWe found an inverse association of genetically proxied IL-17 and periodontitis (odds ratio, 0.84; 95% confidence interval: 0.75-0.94; p = 0.003), which was corroborated after sensitivity analysis for horizontal pleiotropy. ConclusionThe findings suggest that IL-17 protects against initial periodontitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MENDELIAN RANDOMIZATION; IL-17; PATHOGENESIS; NEUTROPHILS; DISEASE; IL-23; cytokines; etiology; interleukin-17; periodontitis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2024 15:37 |
| Last Modified: | 16 Mar 2024 15:37 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60281 |
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