Baumeister, Sebastian-Edgar and Reckelkamm, Stefan Lars and Ehmke, Benjamin and Nolde, Michael and Baurecht, Hansjoerg (2023) Physical activity and the risk of periodontitis: an instrumental variable study. CLINICAL ORAL INVESTIGATIONS, 27 (8). pp. 4803-4808. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
ObjectivesObservational studies suggested an inverse association between physical activity and periodontitis. However, observational studies might be subject to unobserved confounding and reverse causation bias. We conducted an instrumental variable study to strengthen the evidence on the relationship between physical activity and periodontitis.Materials and methodsWe used genetic variants associated with self-reported and accelerometer-assessed physical activity in 377,234 and 91,084 UK Biobank participants, respectively, as instruments. For these instruments, genetic associations with periodontitis were obtained from 17,353 cases and 28,210 controls in the GeneLifestyle Interactions in Dental Endpoints consortium.ResultsWe found no evidence for effects of self-reported moderate-to-vigorous physical activity, self-reported vigorous physical activity, accelerometry "average accelerations," and "fraction of accelerations > 425 milli-gravities" on periodontitis. For example, the odds ratio for self-reported moderate-to-vigorous physical activity was 1.07 (95% credible interval: 0.87; 1.34) in Causal Analysis using Summary Effect Estimates. We conducted sensitivity analyses to rule out weak instrument bias and correlated horizontal pleiotropy.ConclusionsThe study does not support an effect of physical activity on the risk of periodontitis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | AGE; Periodontitis; Physical activity; Etiology; Prevention |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 16 Mar 2024 15:54 |
| Last Modified: | 16 Mar 2024 15:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60291 |
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