Frankewycz, Borys and Bell, Rebecca and Chatterjee, Monideepa and Andarawis-Puri, Nelly (2023) The superior healing capacity of MRL tendons is minimally influenced by the systemic environment of the MRL mouse. SCIENTIFIC REPORTS, 13 (1): 17242. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Murphy Roths Large mice (MRL) exhibit improved tendon healing and are often described as a "super-healer" strain. The underlying mechanisms that drive the superior healing response of MRL remain a controversial subject. We utilized a tendon transplantation model between MRL and "normal-healer" B6-mice to differentiate between the contribution of MRL's innate tendon and systemic environment to its improved healing capacity. Patellar tendons with a midsubstance punch injury were transplanted back into the same animal (autograft) or into an animal of the other strain (allograft). Findings at 4 weeks showed that the innate MRL tendon environment drives its improved healing capacity as demonstrated by improved stiffness and maximum load in MRL-grafts-in-B6-host-allografts compared to B6-autografts, and higher modulus in MRL-autografts compared to B6-graft-in-MRL-host-allografts. Groups with an MRL component showed an increase in pro-inflammatory cytokines in the 3 days after injury, suggesting an early enhanced inflammatory profile in MRL that ultimately resolves. A preserved range of motion of the knee joint in all MRL animals suggests a systemic "shielding effect" of MRL in regard to joint adhesiveness. Our findings 4-weeks post injury are consistent with previous studies showing tissue-driven improved healing and suggest that the systemic environment contributes to the overall healing process.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSTTRAUMATIC ARTHRITIS; MRL/MPJ; REGENERATION; EXPRESSION; INJURY; REPAIR; TISSUE; HEART; MODEL; MICE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Mar 2024 09:29 |
| Last Modified: | 19 Mar 2024 09:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/60307 |
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